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Inflammation is bodys protective reaction caused by invaded external microorganism. Phagocytes play an important role in the inflammatory reaction. Respiratory burst when they are in swallow process or be stimulated, consume oxygen, active hexose phosphorylation slip, release large amounts of reactive oxygen free radical, poison eukaryotic cells, endothelial cell, erythrocyte, fibroblast, platelets and sperm. Leucocyte can be injuried by oxygen free radicals that it generated. SOD can treat pleurisy, reduce pleural effusion and accumulation of leucocyte. SOD also can control arthritis, reduce IgG deposition in the glomerular, inhibit organs permeability change caused by acute bronchitis which xanthine or xanthine oxidase lead to. SOD for the treatment of inflammation has a good prospect for application.
Different types of autoimmune diseases have their different pathogenesis characteristics, but the oxygen Prostaglandin, as well as hydrolases produced by macrophages, monocytes leukocytes and neutrophils play an important role in the disease. Animal experiments have confirmed that SOD and other oxygen free radical scavengers can inhibit the pathogenesis of chronic autoimmune disease.
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