SOD is the key line of defense the organisms oxygen toxicity SOD is the key line of defense the organisms oxygen toxicity,has a good prospects for medicinal application. Medicinal research on SOD at home and abroad, are mainly for the treatment of diseases aused by superoxide anion injury such as ischemia and ischemia-reperfusion sndrome, rheumatoid arthritis and lupus. 1. Treatment of ischemia and ischemia-reperfusion sndrome Ischemia and ischemia-reperfusion sndrome is a very active research field today, it reveals the contradictions that some clinical disease is difficult to explain at past. Such as oronary artery bypass surgery, thrombolysis and variant angina, they are closely related to oxygen. At this time injecting the right amount of SOD can be effective control syndrome appears. SOD can also be applied to the liver, kidney, heart and other organs preservation and transplantation, Replantation of severed limbs, plastic and cosmetic surgical procedure. Research work in this area has a great theoretical significance and practical value.
2. Treatment of inflammatory Inflammation is bodys protective reaction caused by invaded external microorganism. Phagocytes play an important role in the inflammatory reaction. Respiratory burst when they are in swallow process or be stimulated, consume oxygen, active hexose phosphorylation slip, release large amounts of reactive oxygen free radical, poison eukaryotic cells, endothelial cell, erythrocyte, fibroblast, platelets and sperm. Leucocyte can be injuried by oxygen free radicals that it generated. SOD can treat pleurisy, reduce pleural effusion and accumulation of leucocyte. SOD also can control arthritis, reduce IgG deposition in the glomerular, inhibit organs permeability change caused by acute bronchitis which xanthine or xanthine oxidase lead to. SOD for the treatment of inflammation has a good prospect for application.
3、Treatment of auto immune disease Different types of autoimmune diseases have their different pathogenesis characteristics, but the oxygen Prostaglandin, as well as hydrolases produced by macrophages, monocytes leukocytes and neutrophils play an important role in the disease. Animal experiments have confirmed that SOD and other oxygen free radical scavengers can inhibit the pathogenesis of chronic autoimmune disease.
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