Authorities have pointed out that there are 90% of diseases related with excess superoxide radical. As the only enzyme that can eliminate superoxide radical, SOD has attractive prospect of being used as drug, health protection products and additive of various of daily use products. Therefore SOD has inestimable social benefit and economic benefit. Years of researches have proved that it is effective to administer SOD by mouth and this fact provide the theoretical foundation for exploiting health foods supplemented with SOD. Health foods supplemented with SOD have been widely accepted by customers of developed countries such as America, Japan and Europe. In China, SOD products e.g. SOD oral solutions, SOD drink have been produced one after another. The usage of SOD as function factor in cosmetics is very popular now and the SOD’s functions of anti-aging and skin protection have been acknowledged by researchers and governments all over the world. SOD is also expected to be valuable in therapy of various diseases related with oxygen toxicity such as autoimmunity, radiation damage and reperfusion injury. In conclusion, SOD is very valuable in health product, drug, food, cosmetics and bioengineering industry.
Great attention has been paid to SOD since American scientist invented the method of extracting SOD from bovine blood for the first time in 1969.Many countries have invested to research and develop SOD relevant product. A great lot of researches and experiments have shown that SOD has little adverse reaction or toxicity and may serve as native bioactive factor in various fields. At present, developed countries such as America, German, Japan, Canada, Australia and France have approved SOD to be used as drug in clinic. Several dozen of domestic enterprises and research institutes performed a great deal of researches on SOD and some of them have begun to mass-produce SOD . THE Chinese State Food And Drug Administration has approved SOD to be used as drug in clinic and the licensed code is ECI．15．1．1；CAS[9054—89—1].
The main licensed code of SOD by Chinese Ministry of Public Health
The main application fields of SOD
1.Health protection product: SOD may prevent many kinds of diseases and delay aging. Therefore SOD has huge potential economic value as health protection product. There are several this kind of products being supplied overseas and at home.
2.Drug: Because of its great capabilities of eliminating superoxide radical, SOD presents functions of anti-inflammatory, anti-oxidant, anti-aging, anti-radiation and anti-virus. SOD is very effective in therapy of emphysema, diabetes, high pressure oxygen toxicity and hepatopathy. At present, the clinic applications of SOD mainly focus on fields of below.
(1)Autoimmunity: such as rheumatoid arthritis, lupus erythematosus, colonitis, dermatomyositis and emphysema. Especially in case of rheumatoid arthritis and polyarticular arthritis, SOD may serve as substitute of steroid dephlogisticate drugs.
(2)Anti-radiation and anti-tumor: SOD can protect DNA, proteins and cellular membrane from being destroyed by superoxide radical thus it can be used to prevent tumor and therapy radiation damage.
(3)Anti-oxidant: is used to therapy oxygen toxicity, myocardial ischemia and premature infant oxygen toxicity.
(4)Anti-aging: human’s length of life is closely related to the SOD concentration of his body. SOD can delay aging, enhance immunity, delay the appearance of senile plaque and eliminate pigmentation.
3. Food: SOD may be used as additive in subsidiary food and drink thus form a special kind of popular health product, for example the SOD milk powder, SOD capsule and SOD beer. Foods and drink supplemented with SOD have functions of decreasing tiredness, preventing tumor and regulating immunity, blood fat, blood glucose and blood pressure.
4. Daily use product: SOD has become the main component of many daily use products. For example, SOD cosmetic (e.g. DABAO SOD CLEANING MILK) is very popular because it can delay aging, increase skin flexibility and effectively eliminate senile plaque, pigmentation and chloasma.
5. Cigarette: tar oil and nicotine may be removed from cigarette by processed with SOD. It is reported that SOD cigarette with lower tar oil has been produced in Japan.
SOD may entry market as semifinished product or material of food and drug industry.
Our product of SOD is produced by an advanced bioengineering technology different from the method of bovine blood extracting. We have cloned human SOD cDNA into expression plasmid and reformed the gene through genetic engineering. Host cells (E.coli and Yeast) were transformed with above-mentioned plasmid and strain that overexpress bioactive rhSOD was selected. We have developed technology to produce and purify the recombinant SOD protein under the strict working condition. The property of rhSOD is very close to that of native human SOD. Therefore, the new technology entirely avoids hazards of serious immune response or cross infection of pathogenic microorganism from animals such as aftosa and mad cow disease. Furthermore, the new technology abolish the limit of material resource—it is not necessary to grow large area of plants and doesn’t be affected by climate. In a word, our SOD is safe, effective product with high quality and high yield.
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